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Original Research

1. Presence of pyrroloquinazoline alkaloid in Adhatoda vasica attenuates inflammatory response through the downregulation of pro-inflammatory mediators in LPS stimulated RAW 264.7 macrophages

Reddy Amala, Sundaresan Sujatha* ORCID
BioImpacts. 2021;11(1): 15-22. doi: 10.34172/bi.2021.03
PMCID: PMC7803918     PMID: 33469504     Scopus ID: 85099218046    
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LPS stimulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 by binding toTLR-4. iNOS produced enormous nitric oxide (NO) that stimulated COX-2 activity and prostaglandin E2 which further induced the production of pro-inflammatory cytokines leading to inflammation. ALK-F of A. vasica could attenuate iNOS and COX-2 gene expression reducing NO production.
Original Research

2. Mesenchymal stromal cell therapy alone does not lead to complete restoration of skin parameters in diabetic foot patients within a 3-year follow-up period

Nadezhda V. Maksimova ORCID, Anna V. Michenko, Olga A. Krasilnikova ORCID, Ilya D. Klabukov* ORCID, Igor Yu. Gadaev ORCID, Michael E. Krasheninnikov ORCID, Pavel A. Belkov, Aleksey V. Lyundup ORCID
Bioimpacts. 2022;12(1): 51-55. doi: 10.34172/bi.2021.22167
PMCID: PMC8783077     PMID: 35087716     Scopus ID: 85127152579    
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Three-year follow-up of patients, treated for diabetic foot ulcers with mesenchymal stromal cells that revealed absence of ulcer recurrence, neoplasms, and scar contracture. Collagen ultrasound density decreased by 57% and the epidermal thickness increased by 72% in the area of healed ulcers.

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